Detection in molecular communications with ligand receptors under molecular Interference

Abstract Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand receptors infer transmitted messages encoded into concentration of molecules, i.e., ligands. practice, are not ideally selective against target ligands, and in physiological environments, they can interact with multiple types ligands at different reaction rates depending their binding affinity. This molecular cross-talk cause substantial interference MC. Here consider particular scenario, where there non-negligible interferer channel, which have similar receptor-binding characteristics receiver employs single type receptors. We investigate performance four methods, make use statistics ligand-receptor reactions: instantaneous number bound receptors, unbound time durations combination within sampling interval. The performances introduced methods evaluated terms bit error probability varying strength interference, similarity between received difference bit-0 bit-1 transmissions. propose synthetic receptor designs convert required intracellular chemical networks chemically perform computations detection.